Nurse Practitioner Salary in Missouri
Nurse Practitioners in Missouri earn an average of $115,974 per year across 2 metro areas. This is +8.1% lower than the national average.
Average Salary
$115,974
per year
Hourly Rate
$55.76
per hour
vs National
-8.1%
$126,260 national
Salary Range
$74,483
to $169,575
Cost of Living Adjusted Salary
Nominal Salary
$115,974
Cost of Living Index
90
100 = national average
Adjusted Salary
$128,860
purchasing power equivalent
After adjusting for Missouri's cost of living (below average), a Nurse Practitioner's salary of $115,974 has the purchasing power of $128,860 in an average-cost area.
Nurse Practitioner Salary by City in Missouri
| City | Median Salary | Hourly Rate | Entry Level (P10) | Senior (P90) | Employment |
|---|---|---|---|---|---|
| Kansas City, MO | $119,212 | $57.31/hr | $75,418 | $177,961 | 230 |
| St. Louis, MO | $112,736 | $54.20/hr | $73,548 | $161,188 | 257 |
Source: Bureau of Labor Statistics OEWS Survey, 2026. Sorted by median salary (highest first).
Missouri vs National Average
Nurse Practitioner Salary Comparison
Employment in Missouri
There are approximately 487 Nurse Practitioners employed across 2 metro areas in Missouri.
Key Industries: Manufacturing, Healthcare, Agriculture
State Income Tax: 0% - 4.95%
Nurse Practitioner Salary Range in Missouri
Entry Level (10th Percentile)
$74,483
Starting salary for new Nurse Practitioners
Median (50th Percentile)
$115,974
Mid-career Nurse Practitioner salary
Senior (90th Percentile)
$169,575
Top earners in the field
Related Occupations in Missouri
Pharmacist
$126,484
avg in MO
+$10,510 vs Nurse Practitioner
Registered Nurse
$85,940
avg in MO
-$30,034 vs Nurse Practitioner
Dental Hygienist
$85,010
avg in MO
-$30,964 vs Nurse Practitioner
Licensed Practical Nurse
$55,161
avg in MO
-$60,813 vs Nurse Practitioner
Nursing Assistant
$35,373
avg in MO
-$80,601 vs Nurse Practitioner
Nurse Practitioner Salary in Neighboring States
Compare Nurse Practitioner salaries in Missouri with nearby states to find the best opportunities.
More Nurse Practitioner Data
Frequently Asked Questions
What is the average Nurse Practitioner salary in Missouri?
The average Nurse Practitioner salary in Missouri is $115,974 per year ($55.76/hour) based on 2026 data across 2 metro areas. This is 8.1% below the national average of $126,260.
What is the highest paying city for Nurse Practitioners in Missouri?
Kansas City, MO is the highest paying city for Nurse Practitioners in Missouri, with a median salary of $119,212 per year. The lowest paying metro area is St. Louis, MO at $112,736.
What is the salary range for Nurse Practitioners in Missouri?
Nurse Practitioner salaries in Missouri range from $74,483 (entry-level, 10th percentile) to $169,575 (experienced, 90th percentile). The median salary is $115,974 per year.
About This Data
Salary data is sourced from the U.S. Bureau of Labor Statistics Occupational Employment and Wage Statistics (OEWS) survey. State-level averages are calculated from metro area data within Missouri. Figures represent 2026 estimates and may not reflect all employers or self-employed workers. Cost of living adjustments use regional indices to provide purchasing power context.